Week 1 brought several unexpected twists and Fastexy Exchangeturns. The New England Patriots beat the Cincinnati Bengals to everyone's shock. The New Orleans Saints had a massive performance in their win over the Carolina Panthers. Baltimore's Isaiah Likely outshined star teammate Mark Andrews. It was a fresh change of pace, and it made everyone realize that trying to predict what will happen in the NFL is a fool's errand.
So, we're back trying to do exactly that! With Thursday Night Football just around the corner, here are our experts' predictions for every Week 2 matchup.
New to sports betting? USA TODAY readers can claim exclusive promos and bonus codes with the best online sportsbooks and sports betting sites. Here are the NFL betting odds for Week 1, according to the BetMGM NFL odds.
PROP TALK: These are the best prop bets for NFL games this week
NFL Week 2 picks/predictions
Buffalo Bills at Miami Dolphins
Las Vegas Raiders at Baltimore Ravens
Los Angeles Chargers at Carolina Panthers
New Orleans Saints at Dallas Cowboys
Tampa Bay Buccaneers at Detroit Lions
Indianapolis Colts at Green Bay Packers
Cleveland Browns at Jacksonville Jaguars
San Francisco 49ers at Minnesota Vikings
Seattle Seahawks at New England Patriots
New York Jets at Tennessee Titans
New York Giants at Washington Commanders
Los Angeles Rams at Arizona Cardinals
Cincinnati Bengals at Kansas City Chiefs
Pittsburgh Steelers at Denver Broncos
Chicago Bears at Houston Texans
Atlanta Falcons at Philadelphia Eagles
NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.
NFL Week 2 point spreads
Buffalo Bills (+2.5) at Miami Dolphins
Las Vegas Raiders (+9.5) at Baltimore Ravens
Los Angeles Chargers (-6.5) at Carolina Panthers
New Orleans Saints (+6.5) at Dallas Cowboys
Tampa Bay Buccaneers (+7) at Detroit Lions
Indianapolis Colts (-3.5) at Green Bay Packers
Cleveland Browns (+3) at Jacksonville Jaguars
San Francisco 49ers (-6) at Minnesota Vikings
Seattle Seahawks (-3.5) at New England Patriots
New York Jets (-3.5) at Tennessee Titans
New York Giants (+1.5) at Washington Commanders
Los Angeles Rams (+1.5) at Arizona Cardinals
Cincinnati Bengals (+6) at Kansas City Chiefs
Pittsburgh Steelers (-3) at Denver Broncos
Chicago Bears (+7) at Houston Texans
Atlanta Falcons (+6.5) at Philadelphia Eagles
NFL Week 2 moneylines
Buffalo Bills (+115) at Miami Dolphins (-140)
Las Vegas Raiders (+350) at Baltimore Ravens (-450)
Los Angeles Chargers (-275) at Carolina Panthers (+220)
New Orleans Saints (+240) at Dallas Cowboys (-300)
Tampa Bay Buccaneers (+260) at Detroit Lions (-350)
Indianapolis Colts (-185) at Green Bay Packers (+150)
Cleveland Browns (+145) at Jacksonville Jaguars (-175)
San Francisco 49ers (-275) at Minnesota Vikings (+220)
Seattle Seahawks (-185) at New England Patriots (+150)
New York Jets (-190) at Tennessee Titans (+155)
New York Giants (+105) at Washington Commanders (-125)
Los Angeles Rams (+105) at Arizona Cardinals (-125)
Cincinnati Bengals (+200) at Kansas City Chiefs (-250)
Pittsburgh Steelers (-155) at Denver Broncos (+130)
Chicago Bears (+260) at Houston Texans (-350)
Atlanta Falcons (+240) at Philadelphia Eagles (-300)
